Fuziline 是分离自附子侧根中的一种生物碱。

Fuziline shows significant insecticidal activity against Nilaparvata legen and Aphis medicagini. Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.

In the in vitro assays, Fuziline?showed activity against pentobarbital sodium-induced cardiomyocytes damage by?obviously recovering beating rhythm and increasing the cell viability

Neonatal rat cardiomyocytes were cultured in 96-well plates with DMEM media supplemented with 15% FBS.?Cultures were maintained in a 37 °C humidified incubator with 5% CO2.?On the fifth day when the cardiomyocytes were in the growth with rhythmical beating, they were exposed to the medium containing pentobarbital sodium at a concentration of 8 mg/mL.?After 8 min, the medium was replaced with serum free medium including Fuziline?at concentrations of 10 μM, 1 μM, and 0.1 μM, respectively, and incubated for 24 h. Then, 10?μL of MTT solution (5 mg/mL) was added and incubated for 4 h. Absorbance was measured at both 570 nm and 655 nm, and cell viability was evaluated with the deviations between them.

80665-72-1

C24H39NO7

453.576

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years