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Dehydroabietinol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dehydroabietinol图片
CAS NO:3772-55-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品名称
Pomiferin A
Dehydroabietyl alcohol
产品介绍
Dehydroabietinol在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫,IC50为26-27 μM.

产品描述

Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).

体外活性

Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value. CONCLUSIONS: Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products[1].

Cas No.

3772-55-2

分子式

C20H30O

分子量

286.45

别名

Pomiferin A;Dehydroabietyl alcohol

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years