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Gemcitabine-O-Si(di-iso)-O-Mc
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gemcitabine-O-Si(di-iso)-O-Mc图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Gemcitabine-O-Si(di-iso)-O-Mc是抗体偶联药物的一部分，由嘧啶核苷类似物抗代谢药和抗肿瘤剂Gemcitabine和ADClinker连接而成。
Canonical SMILESNC(C=CN1[C@H]2C(F)([C@@H]([C@H](O2)CO[Si](C(C)C)(OCCCCCN3C(C=CC3=O)=O)C(C)C)O)F)=NC1=O
分子式C24H36F2N4O7Si
分子量558.65
溶解度DMSO: 100 mg/mL (179.00 mM); Water:< 0.1 mg/mL (insoluble)
储存条件4℃, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent;), linked via the ADC linker[1].

Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells[1].

[1]. Mathew C. Finniss, et al. A versatile acid-labile linker for antibody-drug conjugate. MedChemComm, Issue 9, 2014.