Theaflavin 3,3'-digallate是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗HSV和HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。

8-Gingerol (TFDG), a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

8-Gingerol has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively) [1].

In vivo, 8-Gingerol reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3].

30462-35-2

C43H32O20

868.709

茶黄素-3,3'-双没食子酸;8-Gingerol;TFDG;8-姜酚

DMSO:10 mg/mL (11.51 mM)
Ethanol:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years