Fiacitabine是单纯疱疹病毒 (HSV) DNA 复制的选择性抑制剂,对HSV1和HSV2的IC50分别为2.5 nM和12.6 nM。
产品描述
Fiacitabine is a selective inhibitor of DNA replication of the herpes simplex virus(HSV) (IC50: 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively).
体外活性
FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloguanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of a virus-specified thymidine kinase. HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay [2].
Cas No.
69123-90-6
分子式
C9H11FIN3O4
分子量
371.1
别名
NSC 382097;非西他滨;FIAC;FOAC
储存和溶解度
DMSO:35 mg/mL (94.31 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years