AB-423 是一种HBV衣壳组装抑制剂，抑制 HBV 复制。在细胞中，EC50/EC90值分别为 0.08-0.27 μM/0.33-1.32 μM。
产品描述
AB-423 is an inhibitor of HBV capsid assembly, and potently inhibits HBV replication (EC50/EC90: 0.08-0.27 μM/0.33-1.32 μM in cells).
体外活性
AB-423 shows an inhibitory effect on relaxed circular DNA production in AML12-HBV10 and HepDE19 cells (EC50s: ～0.260 μM). AB-423 also suppresses cccDNA formation-dependent HBeAg production in the HepBHAe82 assay (EC50: 0.267 μM) and inhibits HBV DNA levels in culture supernatants of HepG 2.2.15 cells (EC50: 0.134 μM).
Cas No.
1572510-80-5
分子式
C17H17F3N2O3S
分子量
386.39
储存和溶解度
DMSO:80 mg/mL (207.05 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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