Dirithromycin是一种红霉素衍生物，是一种具有口服活性的半合成大环内酯类抗生素。它用于治疗许多不同类型的细菌感染。

Dirithromycin is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Dirithromycin在治疗浓度下,增强脂多糖刺激细胞产生的IL1β,在1 μg/mL下分别增强+37 % 和+28%。Dirithromycin在超治疗浓度下,其通过抑制蛋白激酶C而抑制IL1β,抑制率为50%时,Dirithromycin浓度为378 mg/mL,螺旋霉素的浓度为234 mg/mL。

62013-04-1

C42H78N2O14

835.086

Dirithromycine;Diritromicina;LY237216;ASE 136;地红霉素;Dirithromycinum

Ethanol:93 mg/mL (111.4 mM)
H2O:<1 mgml
DMSO:9 mg/mL (10.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years