Nafcillin sodium是一种抗生素，是可逆的β-lactamase抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。

Nafcillin Sodium is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

通过Ser-70与β-内酰胺酶形成共价的酰基酶中间体,Nafcillin sodium可使β-内酰胺酶灭活。Nafcillin（>80 mM,<200s）完全抑制β-内酰胺酶活性。去除Nafcillin后,受抑制的酶可重新被完全激活,速率常数为2×10-3/s (25 ℃)。

7177-50-6

C21H23N2NaO6S

454.47

CL 8491;萘夫西林钠;nafcillin sodium

DMSO:84 mg/mL (184.8 mM)
Ethanol:16 mg/mL (35.2 mM)
H2O:83 mg/mL (182.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years