RSV604 是一种呼吸道合胞病毒抑制剂，可与 RSV 核蛋白结合，靶向核衣壳蛋白的Kd值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性，EC50平均值为 0.8 μM。

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation[1].

RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2].

676128-63-5

C22H17FN4O2

388.402

(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

DMSO:195 mg/mL (502.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years