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RSV604
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RSV604图片
CAS NO:676128-63-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea
产品介绍
RSV604 是一种呼吸道合胞病毒抑制剂,可与 RSV 核蛋白结合,靶向核衣壳蛋白的Kd值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性,EC50平均值为 0.8 μM。

产品描述

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

体外活性

RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation[1].

体内活性

RSV604 resistance mutations in the N protein. RSV604 engaged in two different MoAs in HeLa cells, inhibiting both RSV RNA synthesis and the infectivity of released virus. RSV604 did not inhibit viral RNA synthesis in the RSV subgenomic replicon cells or in the cell-free RNP assay, suggesting that it might act prior to viral replication complex formation. RSV604 did not alter N protein localization in the infected cells[2].

Cas No.

676128-63-5

分子式

C22H17FN4O2

分子量

388.402

别名

(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea

储存和溶解度

DMSO:195 mg/mL (502.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years