KIN101 是 IRF-3 依赖性信号传导的异黄酮激动剂，可诱导 IRF-3 核易位。 它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。

KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.

KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].

610753-87-2

C16H11BrO5S

395.23

3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯;3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

DMSO:32 mg/mL (80.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years