Sisunatovir hydrochloride是一种可口服的 RSV-F 蛋白抑制剂，在体外对一组 RSV-A 和 RSV-B 病毒的临床分离株表现出有效的疗效，对 RSV-A 和 RSV-B 分离株的IC50分别为 1.4 nM 和 1.0 nM。

Sisunatovir HCl is an orally available inhibitor of the RSV-F protein that has exhibited potent efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses in vitro (IC50 = 1.4 nM for RSV-A, IC50 = 1.0 nM for RSV-B).

Sisunatovir HCl exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection[1].

1903763-83-6

C23H23ClF4N4O

482.91

RV521 HCl;Sisunatovir HCl

DMSO:5.5 mg/ml (11.39 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years