Dapivirine是一种二芳基嘧啶非核苷类逆转录酶抑制剂。

Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4]

244767-67-7

C20H19N5

329.407

达匹维林;R147681;TMC120

H2O:<1 mgml
DMSO:32 mg/mL (97.1 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years