Mps1-IN-2 是一种 ATP 竞争性Mps1/PLK1选择性双重抑制剂，对 Mps1 的IC50和Kd值分别为 145 和 12 nM，对 PLK1 的Kd值为 61 nM。

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.

mTOR activity is assayed using LanthaScreen Kinase kit reagents. PI(3)K α, β, γ and δ activity are assayed using the PI(3)K HTRF assay kit. The concentration of INK128 necessary to achieve inhibition of enzyme activity by 50% (IC50) is calculated using concentrations ranging from 20 μM to 0.1 nM (12-point curve). IC50?values are determined using a nonlinear regression model.

1228817-38-6

C26H36N6O3

480.613

DMSO:14.3 mg/mL (30 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years