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PF-3758309 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-3758309 hydrochloride图片
CAS NO:1279034-84-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
PF-03758309 hydrochloride
产品介绍
PF-3758309 hydrochloride 是一种口服的、可逆的 ATP 竞争性PAK4抑制剂,Kd为 2.7 nM,Ki为 18.7 nM。它抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖,具有 PAK4 抑制剂的预期细胞功能。

产品描述

PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

Cas No.

1279034-84-2

分子式

C25H31ClN8OS

分子量

527.09

别名

PF-03758309 hydrochloride

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years