AZ13705339 是一种有效的 PAK1 抑制剂，IC50 为 0.33 nM，Kd 为 0.28 nM。 AZ13705339 以 0.32 nM 的 Kd 结合 PAK2。 AZ13705339 可用于癌症研究。

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death[2]. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion[3].

In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM[1].

2016806-57-6

C33H36FN7O3S

629.75

AZ 13705339;AZ-13705339

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years