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LCH-7749944
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LCH-7749944图片
CAS NO:796888-12-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
GNF-PF-2356
产品介绍
LCH-7749944 是一种PAK4抑制剂,IC50为 14.93 μM。它通过下调 PAK4/c-Src/EGFR/cyclin D1 途径有效抑制人胃癌细胞的增殖,并诱导凋亡。

产品描述

LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM.

体外活性

LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. ?LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.?LCH-7749944 (GNF-PF-2356;?5-50 μM;?24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.??LCH-7749944 (5-20 μM;?12-48 hours) induces apoptosis of SGC7901 cells.

Cas No.

796888-12-5

分子式

C20H22N4O2

分子量

350.41

别名

GNF-PF-2356

储存和溶解度

DMSO:250 mg/mL (713.45 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years