Recilisib 是辐射防护剂,能够提高细胞中Akt和PI3K的活性。
产品描述
Recilisib is a radioprotectant,can activate AKT, PI3K activities in cells.
体外活性
Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.
体内活性
the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice significantly increased by Recilisib Sodium. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure.
Cas No.
334969-03-8
分子式
C16H13ClO4S
分子量
336.79
别名
ON 01210;Ex-RAD;RECILISIB 钠盐
储存和溶解度
DMSO:35.71 mg/mL (106.03 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years