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Mebendazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mebendazole图片
CAS NO:31431-39-7
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
甲苯达唑
Telmin
Vermox
Mebenvet
甲苯咪唑
Pantelmin
产品介绍
Mebendazole是一种hedgehog抑制剂,用作驱虫药。

产品描述

Mebendazole is a hedgehog inhibitor, used as an antihelminthic.

体外活性

mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2].

体内活性

When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2].

细胞实验

When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.(Only for Reference)

Cas No.

31431-39-7

分子式

C16H13N3O3

分子量

295.298

别名

甲苯达唑;Telmin;Vermox;Mebenvet;甲苯咪唑;Pantelmin

储存和溶解度

Ethanol:<1 mgml
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years