Gap 26 是模拟肽,对应于连接蛋白 43 的残基 63-75,是间隙连接阻断剂。
产品描述
Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
体外活性
Oscillatory behaviour was abolished by Gap 26 at concentrations of 100-300 microM (IC50 of 20-30 microM), without a change in average tone. No synergy was evident between peptides corresponding to the extracellular loops, and cytoplasmic loop peptides were biologically inactive [1]. Photoliberating InsP(3) in a single cell within a confluent culture triggered an intercellular calcium wave, which was inhibited by the connexin mimetic peptide gap 26 [2].
Cas No.
197250-15-0
分子式
C70H107N19O19S
分子量
1550.8
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years