Hydroxy-Dynasore 是 Dynasore 结构模拟类似物，是一种改进的，低细胞毒性的Dynamin通用抑制剂，抑制 Dynamin 依赖性转铁蛋白的内吞作用的IC50为 5.7 μM，对大脑重组 Dynamin I 和重组鼠 Dynamin II 的IC50值分别为 0.38 μM 和 2.3μM。

Dyngo-4a , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.

Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. [3]

1256493-34-1

C18H14N2O5

338.319

Dyngo-4a

DMSO:32.2 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years