Boc-C1-PEG3-C4-OBn

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Boc-C1-PEG3-C4-OBn

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2381196-81-0
包装:	500mg
市场价:	5850元

产品介绍

Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) 是一种 PROTAC linker，属于 alkyl/ether 类。Boc-C1-PEG3-C4-OBn可用于合成一系列 PROTAC 分子，例如 PROTAC SGK3 degrader-1 。PROTAC 分子含有两个通过 linker 连接的不同配体; 一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

Cas No.	2381196-81-0
Canonical SMILES	O=C(OC(C)(C)C)COCCOCCOCCCCCCOCC1=CC=CC=C1
分子式	C₂₃H₃₈O₆
分子量	410.54
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 . PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTACDegrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.