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Cimlanod
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cimlanod图片
CAS NO:1620330-72-4
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Cimlanod (BMS-986231) 是一种治疗心力衰竭的第二代硝基 (HNO) 供体。Cimlanod (BMS-986231) 在血液中性 pH 环境下通过 pH 依赖性化学分解传递 HNO。Cimlanod (BMS-986231) 具有正性促力作用和正性肌力以及血管舒张作用。
Cas No.1620330-72-4
别名BMS-986231; CXL-1427
Canonical SMILESO=S(C1=CC=C(O1)C)(NO)=O
分子式C5H7NO4S
分子量177.18
溶解度DMSO: 125 mg/mL (705.50 mM)
储存条件4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects[1][2].

[1]. Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730. [2]. Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031.