Cilobradine hydrochloride是一种HCN通道阻断剂。

Cilobradine hydrochloride is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.

Cilobradine hydrochloride is an HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine hydrochloride inhibits WT mHCN2 channel current by 86%. In contrast, I432A and A425G channel currents were only reduced by 14% and 19%, respectively, by this concentration of Cilobradine hydrochloride. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine hydrochloride (8 ± 2% inhibition)[1].

186097-54-1

C28H39ClN2O5

519.07

DK-AH 269

DMSO:112.5mg/mL (216.7mM)
H2O:91 mg/mL (175.31mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years