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BPO-27 racemate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BPO-27 racemate图片
CAS NO:1314873-02-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
BPO-27 (racemate)
产品介绍
BPO-27 racemate是一种CFTR抑制剂,IC50为8 nM。

产品描述

Bpo-27 racemate is an effective CFTR inhibitor with IC50 of 8 nM.

体外活性

The R enantiomer of BPO-27 inhibits CFTR chloride conductance (IC50: 4 nM), while S enantiomer is inactive. In vitro metabolic stability in hepatic microsomes shows both enantiomers as stable, with less than 5% metabolism in 4 h [1]. (R)-BPO-27 binds near the canonical ATP binding site. Whole-cell patch-clamp studies show linear CFTR currents with a voltage-independent (R)-BPO-27 block mechanism. At a concentration of (R)-BPO-27 that inhibits CFTR chloride current by 50%, the EC50 for ATP activation of CFTR increases from 0.27 to 1.77 mM [2].

体内活性

Following bolus intraperitoneal administration of BPO-27 in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in the kidney [1].

Cas No.

1314873-02-3

分子式

C26H18BrN3O6

分子量

548.34

别名

BPO-27 (racemate)

储存和溶解度

DMSO:6 mg/mL (10.94 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years