AR-C155858 是单羧酸转运蛋白 MCT1 和 MCT2 的抑制剂，Ki分别为2.3和 10 nM。

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

AR-C155858 (10 nM-100 nM) inhibits MCT1/MCT2 C-terminal chimaeras[1]. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner[2]. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM.

496791-37-8

C21H27N5O5S

461.54

DMSO:40 mg/mL (86.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years