ML277 是一种有效的，选择性K(v)7.1 钾离子通道激动剂，EC50为270nM。

ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) [1] Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel[1].

1401242-74-7

C23H25N3O4S2

471.6

ML-277;CID-53347902

DMSO:56 mg/mL (118.75 mM)
DMSO:60 mg/mL (127.23mM)
DMSO:56 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years