Praeruptorin D 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。

Praeruptorin D is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.

Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B powerfully decreases SRE-luciferase activity in a dose-dependent manner. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantly down-regulates the expression of SREBP-1c and SREBP-2 [1]. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9 [2].

The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle-treated mice, although they are still heavier than the chow diet-fed mice. More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar to lovastatin. In addition, compared with vehicle-treated mice, Praeruptorin B significantly lowers the level of TC and TG in the liver, comparable to lovastatin. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B [1].

73069-28-0

C24H26O7

426.465

(+)-川白芷内酯;Praeruptorin D

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years