Azosemide 是磺胺类环利尿剂和NKCC1抑制剂，对 hNKCC1A 和 NKCC1B 的IC50分别为 0.246 和 0.197 μM。

Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B).

Azosemide inhibits the sodium-potassium-chloride-cotransporter human variants hNKCC1B and hNKCC1A [1].

Azosemide shows a shorter terminal half-life (50.9% decrease) and MRT (64.1% decrease), smaller AUC (81.9% decrease), faster CL (454% increase), CLNR (307% increase) and CLR (853% increase) for NARs [2].

27589-33-9

C12H11ClN6O2S2

370.84

DMSO:249 mg/mL (671.44 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years