VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂（Kd：17 μM）。 VBIT-4 可用于治疗凋亡相关疾病（如神经退行性疾病和心血管疾病）。

VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).

VBIT-4 targets the mitochondrial protein VDAC1, inhibits apoptosis and defends against mitochondrial dysfunction.?VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells , IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively).VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.

2086257-77-2

C21H23ClF3N3O3

457.87

DMSO:125 mg/mL (273.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years