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YHO-13351 free base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YHO-13351 free base图片
CAS NO:912288-64-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
500 mg电议

产品介绍
YHO-13351 free base 是 YHO-13177 的水溶性前药,YHO-13177 是 BCRP 的抑制剂。

产品描述

YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .

体内活性

In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models[1].

Cas No.

912288-64-3

分子式

C26H33N3O4S

分子量

483.62

储存和溶解度

DMSO:90mg/mL (186.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years