KS176是选择性高活性乳腺癌耐药蛋白多药转运通道抑制剂，在Pheo A和Hoechst检测中，IC50值分别为0.59和1.39 μM。

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.

Phospholipase D activity is quantified using our established method of measuring the formation of [32P]-radiolabeled PBt. Cellular lipids are extracted and PBt is isolated using our published methods of lipid extraction and thin layer chromatographic separation, respectively. Radioactivity is measured using liquid scintillation counting and quantified as DPM normalized to 106 counts in the total cellular lipid extract or as percentage of control (vehicle-treated cells).

1253452-78-6

C22H19N3O5

405.41

DMSO:35 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years