MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.

MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].

1799706-65-2

C39H65N5NaO8

754.95

Monomethylauristatin F sodium

DMSO:200 mg/mL (265.27 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years