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Chlorpropamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorpropamide图片
CAS NO:94-20-2
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Diabinese
氯磺丙脲
产品介绍
Chlorpropamide 是口服降糖剂,可用于研究非胰岛素依赖型糖尿病。

产品描述

Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.

体内活性

0.2 mM的Chlorpropamide提高了家鼠体内分离出的肝细胞中fructose-2,6-bisphosphate (F-2,6-P2)的浓度。Chlorpropamide通过环AMP-非依赖性机制发挥作用。Chlorpropamide会增强胰岛素对胰高血糖素受激的糖异生的抑制作用。在胰岛素缺乏(30%)或者存在(31%)的情况下,Chlorpropamide都能显著增加葡萄糖代谢和总脂质。

激酶实验

Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter.

Cas No.

94-20-2

分子式

C10H13ClN2O3S

分子量

276.74

别名

Diabinese;氯磺丙脲

储存和溶解度

DMSO:51 mg/mL (184.3 mM)
Ethanol:51 mg/mL (184.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years