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Glipizide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:29094-61-9
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
K 4024
格列吡嗪
CP 28720
产品介绍
Glipizide 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),在 2 型糖尿病的研究中具有价值,但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。

产品描述

Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.

激酶实验

The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106?cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units.

Cas No.

29094-61-9

分子式

C21H27N5O4S

分子量

445.54

别名

K 4024;格列吡嗪;CP 28720

储存和溶解度

Ethanol:<1 mgml
DMSO:82 mg/mL (184 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years