KPT185 是一种选择性 CRM1 抑制剂，可诱导细胞凋亡、细胞周期停滞。

KPT-185 is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

在白血病细胞中（IC50=100 nM-500 nM）,KPT-185显着抑制细胞增殖。在AML细胞系和原发性AML母细胞中,KPT-185能够使细胞周期停滞,并诱导细胞凋亡。对于胰腺癌细胞,KPT-185抑制细胞的增殖,诱导细胞凋亡,但KPT-185不会影响人胰腺导管上皮细胞的生长。

Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)

1333151-73-7

C16H16F3N3O3

355.317

KPT-185;KPT 185

DMSO:66 mg/mL (185.8 mM)
H2O:<1 mgml
Ethanol:66 mg/mL (185.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years