MONNA 是TMEM16A (AnOCTamin-1)阻滞剂，IC50为 80 nM。它在氯离子存在或不存在的情况下诱导啮齿动物抵抗动脉的血管舒张。

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.

The TMEM16A-specific inhibitor, MONNA, hyperpolarised the membrane potential in U46619.?MONNA, T16Ainh -A01, and Ani9 attenuated 5-HT/U46619-induced contractions.?MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations.?TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats.?MONNA diminished this increased sensitivity to U46619 and 5-HT[1].

1572936-83-4

C18H14N2O5

338.319

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years