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1,3-Dibromo-5,5-dimethylhydantoin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,3-Dibromo-5,5-dimethylhydantoin图片
CAS NO:77-48-5
包装:500mg
市场价:450元

产品介绍
1,3-Dibromo-5,5-dimethylhydantoin是一种PROTAClinker，属于alkylchain类。可用于合成PROTAC分子。
Cas No.77-48-5
别名二溴海因
Canonical SMILESO=C1N(Br)C(C(C)(C)N1Br)=O
分子式C5H6Br2N2O2
分子量285.92
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562