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Abeprazan hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abeprazan hydrochloride图片
CAS NO:1902954-87-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
DWP14012 hydrochloride
Fexuprazan hydrochloride
产品介绍
Abeprazan hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂,用于研究与酸相关的疾病。

产品描述

Abeprazan hydrochloride is a potassium-competitive acid blocker. It inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. It is developed as a potential alternative to a proton pump inhibitor for the treatment of acid-related diseases.

体外活性

The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].

体内活性

Abeprazan hydrochloride inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models, and heidenhain pouch dog models[1].

Cas No.

1902954-87-3

分子式

C19H18ClF3N2O3S

分子量

446.87

别名

DWP14012 hydrochloride;Fexuprazan hydrochloride

储存和溶解度

DMSO:22.5mg/mL (50.4mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years