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Rabeprazole sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rabeprazole sodium图片
CAS NO:117976-90-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
雷贝拉唑钠
Habeprazole Sodium
Dexrabeprazole Sodium
Rebeprazole sodium
Aciphex Sodium
LY307640 sodium
产品介绍
Rabeprazole sodium 是一种质子泵抑制剂,不可逆地抑制胃 H+/K+-ATPase,可研究胃溃疡和胃食管反流。它诱导细胞凋亡,也抑制尿苷核苷核糖水解酶 ,IC50为 0.3 μM。

产品描述

Rabeprazole sodium is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.

体外活性

Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2].

体内活性

Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1].

细胞实验

Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)

Cas No.

117976-90-6

分子式

C18H20N3NaO3S

分子量

381.43

别名

雷贝拉唑钠;Habeprazole Sodium;Dexrabeprazole Sodium;Rebeprazole sodium;Aciphex Sodium;LY307640 sodium

储存和溶解度

H2O:70 mg/mL (183.5 mM)
Ethanol:71 mg/mL (186.1 mM)
DMSO:71 mg/mL (186.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years