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S-Methylglutathione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S-Methylglutathione图片
CAS NO:2922-56-7
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
5mg电议
10mg电议
25mg电议

产品介绍
S-Methylglutathione 是一种 S 取代的谷胱甘肽,一种比 GSH 更强的亲核试剂 (nucleophile)。S-Methylglutathione 对乙二醛酶 1 (glyoxalase 1) 有抑制作用。
Cas No.2922-56-7
Canonical SMILESO=C(O)CNC([C@H](CSC)NC(CC[C@@H](C(O)=O)N)=O)=O
分子式C11H19N3O6S
分子量321.35
溶解度Water: 35.71 mg/mL (111.12 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1[2].

S-Methylglutathione (GS-Me) is a stronger nucleophile than GSH, which is rationalized by the more positive inductive effect of the methyl group[1].

[1]. Foye WO, et al. Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents. J Pharm Sci. 1984 Apr;73(4):559-61. [2]. Milos I. Djuran,et al. Reactivity of chloro- and aqua(diethylenetriamine)platinum(II) ions with glutathione, S-methylglutathione, and guanosine 5'-monophosphate in relation to the antitumor activity and toxicity of platinum complexes. Inorg. Chem. 1991, 30, 12, 2648-2652