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Thalidomide 4'-oxyacetamide-PEG4-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thalidomide 4'-oxyacetamide-PEG4-amine图片
CAS NO:2245697-85-0
包装:25mg
市场价:1305元

产品介绍
Thalidomide 4'-oxyacetamide-PEG4-amine 是一种合成的 E3 连接酶配体-接头偶联物,包含基于 Thalidomide 的 cereblon 配体和接头,可用于 PROTAC 的合成。
Cas No.2245697-85-0
Canonical SMILESO=C(C1=C(C(OCC(NCCOCCOCCOCCOCCN)=O)=CC=C1)C2=O)N2C(C(N3)=O)CCC3=O.Cl
分子式C25H34N4O10.HCl
分子量587.02
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 2 PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Winter et al (2015) Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348 1376 PMID:25999370 |Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID:28302825