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LNT 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LNT 1图片
CAS NO:824983-91-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LNT 1 (compound 1) 是一种瓣状内切酶 1 (FEN1) 抑制剂。 LNT 1 与 FEN1 的活性位点结合,部分通过 Mg2+ 离子的配位实现抑制。
Cas No.824983-91-7
Canonical SMILESON1C(N(C2=C(C1=O)SC=C2)CC3COC4=CC=CC=C4O3)=O
分子式C15H12N2O5S
分子量332.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.

Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID:27526030 |Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID:28628639