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L-Azidohomoalanine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Azidohomoalanine hydrochloride图片
CAS NO:942518-29-8
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
50mg电议
100mg电议

产品介绍
L-叠氮高丙氨酸盐酸盐是一种基于烷基链的 PROTAC 接头,可用于 PROTAC 的合成。
Cas No.942518-29-8
别名(2S)-2-氨基-4-叠氮基丁酸盐酸盐
Canonical SMILESN[C@H](C(O)=O)CCN=[N+]=[N-].Cl
分子式C4H8N4O2.HCl
分子量180.59
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Unnatural amino acid. Incorporated into proteins during de novo protein synthesis, with no effect on protein degradation. Requires methionine-free medium for efficient incorporation. Substrate for wild-type methionyl-tRNA synthetase (MetRS) in vivo. Can be used in BONCAT (bio-orthogonal non-canonical amino acid tagging) for the identification of newly synthesized proteins.

Dieterich et al (2006) Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc.Natl.Acad.Sci.U.S.A. 103 9482 PMID:16769897 |Lang & Chin et al (2014) Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem.Rev. 114 4764 PMID:24655057 |Wang et al (2017) Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat.Protoc. 12 279 PMID:28079880