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GOT1 inhibitor-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GOT1 inhibitor-1图片
CAS NO:732973-87-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GOT1inhibitor-1(compound2c)是一种戊酸衍生物,是一种新型的、有效的、非共价的谷氨酸草酰乙酸转氨酶1(GOT1)抑制剂,IC50为8.2uM。GOT1inhibitor-1可用于胰腺导管腺癌(PDAC)的研究。
Cas No.732973-87-4
别名N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
Canonical SMILESO=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4
分子式C19H19ClN4O
分子量354.83
溶解度DMSO: 125 mg/mL (352.28 mM); Water:< 0.1 mg/mL (insoluble)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1].

PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research.In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM[1].

[1]. Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678