JH-II-127是一种高选择性的脑渗透性LRRK2 抑制剂，抑制野生型LRRK2、G2019S LRRK2和 A2016T LRRK2，IC50 值分别为6.6 nM、2.2 nM和 47.7 nM。

JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),

JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro.?It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

1700693-08-8

C19H21ClN6O3

416.87

DMSO:30 mg/mL (71.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years