HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S抑制剂，IC50分别为20.3 nM和3.2 nM。

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells.?When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.

1351758-81-0

C17H20ClN5O3

377.83

[4-[[5-氯-4-(甲基氨基)-2-嘧啶基]氨基]-3-甲氧基苯基]-4-吗啉基甲酮

DMSO:50 mg/mL (132.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years