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Alendronic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alendronic acid图片
CAS NO:66376-36-1
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
100mg电议

产品介绍
Alendronic acid,一种双膦酸盐,是法呢基二磷酸合酶 (FDPS) 抑制剂。Alendronic acid 抑制破骨细胞介导的骨吸收。Alendronic acid 对绝经后骨质疏松症,恶性高钙血症和 Paget 病具有疗效。
Cas No.66376-36-1
别名阿仑膦酸
Canonical SMILESOC(P(O)(O)=O)(CCCN)P(O)(O)=O
分子式C4H13NO7P2
分子量249.1
溶解度Water: 8.33 mg/mL (33.44 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget's disease[1].

[1]. Teixeira S, et al. Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma. Pharmaceutics. 2020 Mar 24;12(3). pii: E293. [2]. Duckworth AD, et al. Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial. J Bone Miner Res. 2019 Jun;34(6):1025-1032.