AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).

T13564L2

C30H43N7O11S3

773.9

AZ7550 trimesylate salt;AZ7550 Mesylate

DMSO:25 mg/mL (32.30 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years