NCB0846 是一种具有口服活性的TNIK抑制剂(IC50:21?nM)。

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.

1792999-26-8

C21H21N5O2

375.432

NCB 0846

DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years