Raf709 是Raf抑制剂，抑制BRaf和CRaf，IC50分别为 0.4 和 0.5 nM，具有抗肿瘤活性。

RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.

The invention provides compounds (e.g., RAF709) that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers[1].

1628838-42-5

C28H29F3N4O4

542.55

DMSO:91 mg/mL(167.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years